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Medications that inhibit CYP2D6 activity, for instance paroxetine and quinidine, may possibly lead to lowered clearance of oxycodone which could lead to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Ritonavir or lopinavir/ritonavir tremen